Studies indicate that ingested oral hairpieces cyanocobalamin tablets are ineffective in the treatment of allergic disease, perhaps because once ingested, they are directly metabolized in the liver. When B12 is delivered via injection or lozenge it passes throughout the bloodstream before arriving at for the men liver. It is during this first pass in its native form that it is believed to exert its therapeutic effect. CLINICAL RESEARCH: "The World Health Organization (WHO) hairpieces and for recognizes allergic rhinitis (hay fever), men sinusitis, hairpieces and for asthma,...conjunctivitis, men urticaria, eczema, dermatitis (contact and atopic)...allergic and migraine headache...as diseases in which hairpieces IgE-mediated allergy may be involved."1 In 1988, asthma and allergic rhinitis subjects were treated for with B12. Total IgE, specific IgE and pulmonary lung functions were taken at days 45, 150 and 180 men from baseline. Eight of the 9 subjects hairpieces had reduced for IgE. 2 In 1989 open label studies at two sites in Riverside County, CA in 1989. Sixteen of the 17 subjects had lowered IgE levels from Day 0 to Day 30.3

In men 1990 study hairpieces in San Diego, CA the 5 active subjects with allergic rhinitis had a lowered total serum IgE from Day 0 to Day 90 while 4 placebo subjects, (2 with allergic rhinitis, 1 with asthma for and 1 with both), had flat or increased IgE levels.4 In a randomized, double-blind, placebo controlled study of symptoms and serum IgE men levels in San Diego, hairpieces CA in mid-1991, subjects had allergic rhinitis and/or asthma. Serum was drawn at Day 0 and Day 30. Seven of the 10 active treated subjects had a reduction in total serum IgE levels. In 10 placebo treated subjects, 5 had levels of total serum IgE that stayed the same (plus for or minus 5%), 3 decreased and 2 increased.5 Statistical analysis of the open-label study as well as the double-blind randomized placebo controlled study have shown a significant effect of vitamin men B12 in lowering serum IgE concentrations.