Studies indicate that ingested human oral cyanocobalamin tablets are ineffective in the treatment of allergic hair disease, perhaps because once ingested, they are directly metabolized in the liver. piece When B12 is delivered via injection or lozenge human it passes throughout the bloodstream before hair arriving at the liver. It is during this first pass in its native form that it is believed to exert its therapeutic piece effect. CLINICAL RESEARCH: "The World Health Organization (WHO) recognizes allergic rhinitis (hay fever), sinusitis, asthma,...conjunctivitis, urticaria, eczema, dermatitis (contact and atopic)...allergic human and migraine headache...as diseases in which IgE-mediated hair allergy piece may be involved."1 In 1988, asthma and allergic rhinitis subjects were human treated with B12. Total IgE, specific IgE and pulmonary lung functions were taken at days 45, 150 and 180 from baseline. Eight of the hair 9 subjects had reduced IgE. 2 In 1989 piece open label studies at two sites in Riverside County, CA in 1989. Sixteen of the 17 subjects had lowered IgE levels from Day 0 to Day 30.3

In human 1990 study in San hair Diego, CA the 5 active piece subjects with human allergic rhinitis had a lowered total serum IgE from Day 0 to Day 90 while 4 placebo subjects, (2 with allergic rhinitis, 1 with asthma and 1 with both), had flat or increased IgE levels.4 In a randomized, double-blind, hair placebo controlled study of symptoms and serum piece IgE human levels in San Diego, CA in mid-1991, subjects hair had allergic rhinitis and/or asthma. Serum was drawn at Day 0 and Day 30. Seven of the 10 active treated subjects had a reduction in total serum IgE levels. In 10 placebo treated piece subjects, 5 had levels of total human serum IgE that stayed the same (plus or minus 5%), 3 decreased and 2 increased.5 Statistical analysis of the open-label study as well hair as the double-blind piece and human randomized placebo hair controlled study have shown a significant effect of vitamin B12 piece in lowering serum IgE concentrations.